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Grapefruit and Orange Flavonoids
Published February 10th, 2007
A study published in the Journal of Nutritional Biochemistry reports that naringenin, a flavonoid compound found in grapefruit and oranges may help prevent cancer, and not just because of its antioxidant properties. Apparently naringenin induced DNA repair in human prostate cancer cell cultures (cell line LNCaP).
The degree of repair was measured by the ratio between deoxyguanosine (dG) and 8-hydroxydeoxyguanosine (8-OH-dG). The former is found in normal DNA, while the latter is the product of hydroxyl radical attack – found in damaged DNA.
After 24 hours of exposure to 80 micromoles per liter of naringenin, the ratio of 8 -OH-dG to dG had decreased by 24 per cent, showing that the flavonoid had stimulated DNA repair.
Naringenin is proposed to perform DNA repair by stimulating base excision repair, as indicated by increases in two of the main enzymes in the BER pathway, DNA poly-beta and hOGG1.
